Current PTCTC Protocols
Below is a listing of current protocols that the PTCTC is involved in.
Current Protocols
Study Title | Study Chairs | Status | More Information |
|---|---|---|---|
Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome | Sherwin Chan, MD, PhD | Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT03865589 |
ONC1701: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children and Young Adults with B-ALL (EndRAD) | Hisham Abdel-Azim, MD, MS
Troy C. Quigg, DO, MS
| Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT03509961 |
Pilot Study using Induction Chemo-immunotherapy Followed by Consolidation with Reduced Toxicity Conditioning and Allogeneic Stem Cell Transplant in Advanced Stage Mature Non-anaplastic T-cell or NK Lymphoma/Leukemia in Children, Adolescents, And Young Adults
A NK/T-cell Lymphoma/Leukemia Consortium Study in Collaboration with the Pediatric Transplantation & Cellular Therapy Consortium
(NYMC575)
| Ana C. Xavier, MD
Mitchell S. Cairo, MD
| Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT03719105 |
ONC1401: The Role of KIR-favorably Mismatched Haploidentical Transplantation and KIR Polymorphisms in Determining Outcomes of Children with ALL/AML/MDS Undergoing Allogeneic hematopoietic Cell Transplantation | Michael A. Pulsipher, MD
Wing Leung, MD, PhD
| Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT02646839 |
GVH 1701: Multi-center phase II randomized controlled trial of naïve T cell depletion for prevention of chronic graft-versus-host disease in children and young adults | Marie Bleakley, MD PhD | Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT03779854 |
GVHD 1901: Biomarker Verification in Pediatric Chronic Graft-Versus-Host Disease ABLE 2.0 | Kirk Schultz, MD
Andrew C. Harris, MD
| Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT04372524 |
Vorinostat for Acute GVHD Prevention in Children, Adolescents, & Young Adults | Sung Won Choi, MD, MS | Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT03842696 |
NMD 1801: A randomized trial of low versus moderate exposure busulfan for infants with severe combined immunodeficiency (SCID) receiving TCRαβ+/CD19+ depleted transplantation:
A Phase II study by the Primary Immune Deficiency
Treatment Consortium (PIDTC) and Pediatric Transplantation
& Cellular Therapy Consortium (PTCTC)
PIDTC “CSIDE” Protocol
(Conditioning SCID Infants Diagnosed Early)
| Sung-Yun Pai, MD
Michael Pulsipher, MD
| Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT03619551 |
NMD 1601: Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia (TransIT) | Michael Pulsipher, MD
David A Williams, MD
| Open | https://clinicaltrials.gov/ct2/show/NCT02845596 |
ONC 1801: Phase 1/2 Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults with Relapsed/Refractory Acute Myeloid Leukemia | Richard Aplenc, MD PhD
Nirali Shah, MD, MHSc
| Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT03971799 |
A Pilot Study in the Treatment of Refractory Viral (CMV, Adeno, BK or EBV) Infections with Related Donor CMV Specific Cytotoxic T-cells (CTLs) in Children, Adolescents and Young Adult Recipients Post AlloSCT or with Primary Immune Deficiencies | Julie Talano, MD
Nancy Bunin, MD
Mitchell S. Cairo, MD
| Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT04197596 |
CT:2001: A Phase II Pilot Study of Donor-Derived Ex-Vivo Expanded Natural Killer Cell Infusions in Children and Young Adults with High-Risk Acute Myeloid Leukemia Receiving Myeloablative HLA-Haploidentical Hematopoietic Cell Transplant: A Multicenter Pediatric
Transplantation and Cellular Therapy Consortium (PTCTC) Study (EXCEL Trial)
| Monica Thakar, MD
Hemalatha Rangarajan, MD
| Open not yet recruiting | https://clinicaltrials.gov/ct2/show/results/NCT04836390 |
Randomized Controlled Trial of Olanzapine for the Control of Chemotherapy-induced Vomiting in Children Receiving Cyclophosphamide-based Conditioning for Allogeneic HSCT | L. Lee Dupuis, RPh, PhD | Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT03118986 |
Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome | Sherwin Chan, MD, PhD | Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT03865589 |
PTCTC centers participate in the following Blood and Marrow Transplant Clinical Trials Network (BMT CTN) trials
Protocol Title | Study Chairs | Status | More Information |
|---|---|---|---|
BMT CTN Protocol 1702 - Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation | Stephanie Lee, MD
Stefan Ciurea, MD
| Open and enrolling | https://clinicaltrials.gov/ct2/show/NCT03904134 |
BMT CTN Protocol 1507- Reduced Intensity Conditioning for Haploidentical Bone Marrow Transplantation in Patients with Symptomatic Sickle Cell Disease | Robert Brodsky, MD
Michael DeBaun, MD
Adetola Kassim, MD
Mark Walters, MD
| Open and enrolling | https://clinicaltrials.gov/ct2/show/record/NCT03263559 |
BMT CTN 1904 - Hematopoietic Cell Transplantation Using Treosulfan-Based Conditioning for the Treatment of Bone Marrow Failure Diseases | Lauri Burroughs, MD
Margaret MacMillian, MD
| Open and enrolling |