Current PTCTC Protocols

Below is a listing of current protocols that the PTCTC is involved in. 

Current Protocols

Study Title
Study Chairs
Status
More Information
Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome
Sherwin Chan, MD, PhD
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT03865589
ONC1701: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children and Young Adults with B-ALL (EndRAD)
Hisham Abdel-Azim, MD, MS Troy C. Quigg, DO, MS
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT03509961
Pilot Study using Induction Chemo-immunotherapy Followed by Consolidation with Reduced Toxicity Conditioning and Allogeneic Stem Cell Transplant in Advanced Stage Mature Non-anaplastic T-cell or NK Lymphoma/Leukemia in Children, Adolescents, And Young Adults A NK/T-cell Lymphoma/Leukemia Consortium Study in Collaboration with the Pediatric Transplantation & Cellular Therapy Consortium (NYMC575)
Ana C. Xavier, MD Mitchell S. Cairo, MD
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT03719105
ONC1401: The Role of KIR-favorably Mismatched Haploidentical Transplantation and KIR Polymorphisms in Determining Outcomes of Children with ALL/AML/MDS Undergoing Allogeneic hematopoietic Cell Transplantation
Michael A. Pulsipher, MD Wing Leung, MD, PhD
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT02646839
GVH 1701: Multi-center phase II randomized controlled trial of naïve T cell depletion for prevention of chronic graft-versus-host disease in children and young adults
Marie Bleakley, MD PhD
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT03779854
GVHD 1901: Biomarker Verification in Pediatric Chronic Graft-Versus-Host Disease ABLE 2.0
Kirk Schultz, MD Andrew C. Harris, MD
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT04372524
Vorinostat for Acute GVHD Prevention in Children, Adolescents, & Young Adults
Sung Won Choi, MD, MS
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT03842696
NMD 1801: A randomized trial of low versus moderate exposure busulfan for infants with severe combined immunodeficiency (SCID) receiving TCRαβ+/CD19+ depleted transplantation: A Phase II study by the Primary Immune Deficiency Treatment Consortium (PIDTC) and Pediatric Transplantation & Cellular Therapy Consortium (PTCTC) PIDTC “CSIDE” Protocol (Conditioning SCID Infants Diagnosed Early)
Sung-Yun Pai, MD Michael Pulsipher, MD
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT03619551
NMD 1601: Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia (TransIT)
Michael Pulsipher, MD David A Williams, MD
Open
https://clinicaltrials.gov/ct2/show/NCT02845596
ONC 1801: Phase 1/2 Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults with Relapsed/Refractory Acute Myeloid Leukemia
Richard Aplenc, MD PhD Nirali Shah, MD, MHSc
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT03971799
A Pilot Study in the Treatment of Refractory Viral (CMV, Adeno, BK or EBV) Infections with Related Donor CMV Specific Cytotoxic T-cells (CTLs) in Children, Adolescents and Young Adult Recipients Post AlloSCT or with Primary Immune Deficiencies
Julie Talano, MD Nancy Bunin, MD Mitchell S. Cairo, MD
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT04197596
CT:2001: A Phase II Pilot Study of Donor-Derived Ex-Vivo Expanded Natural Killer Cell Infusions in Children and Young Adults with High-Risk Acute Myeloid Leukemia Receiving Myeloablative HLA-Haploidentical Hematopoietic Cell Transplant: A Multicenter Pediatric Transplantation and Cellular Therapy Consortium (PTCTC) Study (EXCEL Trial)
Monica Thakar, MD Hemalatha Rangarajan, MD
Open not yet recruiting
https://clinicaltrials.gov/ct2/show/results/NCT04836390
Randomized Controlled Trial of Olanzapine for the Control of Chemotherapy-induced Vomiting in Children Receiving Cyclophosphamide-based Conditioning for Allogeneic HSCT
L. Lee Dupuis, RPh, PhD
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT03118986
Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome
Sherwin Chan, MD, PhD
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT03865589

PTCTC centers participate in the following Blood and Marrow Transplant Clinical Trials Network (BMT CTN) trials

Protocol Title
Study Chairs
Status
More Information
BMT CTN Protocol 1702 - Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation
Stephanie Lee, MD Stefan Ciurea, MD
Open and enrolling
https://clinicaltrials.gov/ct2/show/NCT03904134
BMT CTN Protocol 1507- Reduced Intensity Conditioning for Haploidentical Bone Marrow Transplantation in Patients with Symptomatic Sickle Cell Disease
Robert Brodsky, MD Michael DeBaun, MD Adetola Kassim, MD Mark Walters, MD
Open and enrolling
https://clinicaltrials.gov/ct2/show/record/NCT03263559
BMT CTN 1904 - Hematopoietic Cell Transplantation Using Treosulfan-Based Conditioning for the Treatment of Bone Marrow Failure Diseases
Lauri Burroughs, MD Margaret MacMillian, MD
Open and enrolling