Current PTCTC Protocols

Below is a listing of current protocols that the PTCTC is involved in. 

Current Protocols

Protocol
ClinicalTrials.gov NCT Number
Status
More Information
BMT CTN 1702: Clinical Transplant-Related Long-Term Outcomes of Alternative Donor Allogeneic Transplantation
NCT03904134
Active
https://web.emmes.com/study/bmt2/protocol/1702_protocol/1702_protocol.html
BMT CTN 1507: Haploidentical Bone Marrow Transplantation in Sickle Cell Patients
NCT03263559
Active
https://web.emmes.com/study/bmt2/protocol/1507_protocol/1507_protocol.html
BMT CTN 1503: Comparing Bone Marrow Transplantation in Standard Care in Adolescents with Severe Sickle Cell Disease
NCT02766465
Closing Soon
https://web.emmes.com/study/bmt2/protocol/1503_protocol/1503_protocol.html
Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children and Young Adults with B-ALL (EndRAD)
NCT03509961
Recruiting
https://clinicaltrials.gov/ct2/show/NCT03509961
Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia (TransIT)
NCT02845596
Recruiting
https://clinicaltrials.gov/ct2/show/NCT02845596
The Role of KIR-favorably Mismatched Haploidentical Transplantation and KIR Polymorphisms in Determining Outcomes of Children with ALL/AML/MDS Undergoing Allogeneic hematopoietic Cell Transplantation
NCT02646839
Enrolling by Invitation
https://clinicaltrials.gov/ct2/show/NCT02646839
Randomized trial of low versus moderate exposure busulfan for infants with severe combined immunodeficiency (SCID) receiving TCRαβ+/CD19+ depleted transplantation: A Phase II study by the Primary Immune Deficiency Treatment Consortium (PIDTC) and Pediatric Blood and Marrow Transplant Consortium (PBMTC)
NCT03619551
Recruiting
https://clinicaltrials.gov/ct2/show/NCT03619551
Phase 1/2 Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults with Relapsed/Refractory Acute Myeloid Leukemia
NCT03971799
Recruiting
https://clinicaltrials.gov/ct2/show/NCT03971799
Multi-center phase II randomized controlled trial of naïve T cell depletion for prevention of chronic graft- versus-host disease in children and young adults
NCT03779854
Recruiting
https://clinicaltrials.gov/ct2/show/NCT03779854
Antiviral Cellular Therapy for Enhancing T-cell Reconstitution Before or After Hematopoietic Stem Cell Transplantation (ACES)
NCT03475212
Recruiting
https://clinicaltrials.gov/ct2/show/NCT03475212